Regenerative Medicine Platelet-Pich Plasma (PRP) and mesenchymal stem cells

Regenerative medicine is a particular branch of medicine, which aims to regenerate cells, tissues and organs through the use of advanced techniques.

Chronic degenerative joint diseases, such as osteoarthritis, occur when cartilage, the joint’s natural cushioning system, degenerates, causing:

  • Pain
  • Rigidity
  • Loss of flexibility


Platelet-Rich Plasma (PRP) or platelet gel is an autologous mixture, i.e. a preparation that is obtained by drawing blood from the patient himself. The preparation is injected with a needle directly into the joint surfaces; its effect is to stimulate the growth of new cartilage cells, which will replace the deteriorated ones.

Responsible for these reparative processes are the so-called platelet growth factors (PDGF, TGF-β, IGF I/II, FGBF, EGF); the goal of PRP production is to obtain a gel in which the concentration of platelets is as high as 95%. Thus, PRP is a substance rich in platelet growth factors.

Scientific studies have shown that the higher concentration of growth factors in PRP can potentially accelerate the healing process when injected into the injured area.

Mesenchymal cell therapy is based on the same mechanism of autologous harvesting and subsequent infiltration through a needle, but the harvesting that is performed is a small liposuction, and the tissue that is then infiltrated is therefore of adipose in nature.

This procedure has advantages and disadvantages over the PRP procedure, the most obvious of which is its greater invasiveness: liposuction is in fact a surgical procedure, which although short and simple must be performed in the operating theatre.

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